The problem with these backups can come when the game uses the SecuROM protection system, because if it detects the presence of a virtual reading drive the game will automatically stop working. To avoid this you can resort to Virtual CD Hide.
This small executable will open in the taskbar and is shown as a CD icon with a tick mark, if you right click on the icon a context menu will open with three options: hide the virtual drives, show the virtual drives and exit. If you select the first option the icon will change to that of CD with a cross, and the virtual drives will no longer be visible for the SecuROM protection system.
Therefore, if you want an application that will allow you to use your disc images with the SecuROM protection from a virtual drive, download Virtual CD Hide.